Synthesis, properties, and prospective medical applications of metal-organic frameworks
Abstrakt
Researchers strive to develop novel delivery systems for therapeutic substances and new therapies. The aim is to maximize the efficacy and effectiveness of conducted therapy while maintaining controlled drug delivery profiles and minimizing the side effects of therapy. Currently, numerous methods of drug administration are in use. Simultaneously, novel potential drug cargos, such as metal-organic frameworks, quantum dots, carbon nanotubes, ordendrimer s, are under vigorous investigation. This paper aims to consider metal-organic frameworks (MOFs), which are composed of metal ions/clusters coordinated to organic linkers forming one-, two-, or three-dimensional materials with unprecedentedly large specific surface areas, high porosity, and a capability of a high degree of modifications. They have found many potential applications, and due to their low toxicity, high biocompatibility, and bioavailability, they are considered materials of the “medicine of the future”.